Fig. 9.
Short-term use of AMPAkines does not lead to conditioned place preference. (A) Rats were conditioned for 4 days with alternating CX546 (10 mg/kg) and control treatments in the morning and afternoon, and then they were tested on the following day for place preference. Rats did not develop place preference for the chamber paired with AMPAkine treatment. Two-way ANOVA with repeated measures and Bonferroni post-test was used to compare preconditioning with test values: n = 11; P = 0.9046; N/S = nonsignificant. (B) Rats developed place preference for the chamber paired with morphine treatment (subcutaneous injection, 4 mg/kg): n = 10; P = 0.0349. *P < 0.05.