Fig. 3.
(A) Connectivity maps according to the seed-to-voxel analysis in the left and right executive control networks (LECn and RECn) across experimental conditions, namely baseline (wake state [W1]), light sedation (S1), and deep sedation (S2). For display purposes, results are thresholded at an uncorrected P < 0.001 and are shown on slices of a canonical structural T1 magnetic resonance scan in the three planes, as well as on a three-dimensional representation of the cortical surface. Color scales correspond to T values of statistical parametric mapping group maps. x, y, and z indicate the Montreal Neurological Institute coordinates of the point located at the crossing of blue lines. Brain regions showing a significant negative correlation between the increasing depth of ketamine sedation and the connectivity with LECn or RECn are also shown (correlation between depth of ketamine sedation and connectivity of concerned region with remaining network [Corr.]), using a blue scale. (B) Connectivity maps obtained after seed-to-seed analysis and using predefined regions of interest (ROIs) of the LECn and RECn for W1, S1, and S2. Those ROIs are represented by color circles projected on a canonical axial brain slice. The lines indicate connectivity, and their color and thickness vary as a function of the associated T value. A color scale of T values is defined for each image and appears on top of them. (C) Size β and 95% CI (error bars) of some of the relevant effects observed in ROIs of the LECn and RECn across experimental conditions (W1, S1, and S2) and for the correlation analysis. Effect sizes are shown for connectivity between those ROIs and ipsilateral (LECn and RECn) or contralateral (LECn to RECn, RECn to LECn) executive control network. BrSt = brainstem; Cere = cerebellum; LAG/RAG = left and right angular gyrus; LDLPFC/RDLPFC = left and right dorsolateral prefrontal cortices; LIPL/RIPL = left and right inferior parietal lobules; LPMC/RPMC = left and right premotor cortices; LPrec/RPrec = left and right precuneus; LThal/RThal = left and right thalamus; MCingC = midcingulate cortex.