Fig. 5.
The effect of prothrombin complex concentrate (PCC) and recombinant factor VIIa (FVIIa) on the peak and rate of thrombin generation depends on the level of dabigatran (Dabi) present. This figure shows the effects of different concentrations of added FVIIa or PCC (as indicated by the labels for the X-axis) in the presence of 1.0 µM (open circles superimposed on gray bars) or 2.0 µM dabigatran (black diamonds superimposed on white bars). The data for the peak thrombin generation are shown in (A) and for the rate of thrombin generation in (B). The bars are the means (± SD) of four separate experiments using cells and plasma from different donors. The symbols represent the mean of three triplicate values in each individual experiment. The data are expressed as a percent of the control value (no dabigatran, PCC, or FVIIa added) in the same experiment. *P < 0.05 compared to control using two-way repeated-measures ANOVA with Bonferroni correction for multiple comparisons.