Fig. 5.
Emulsified isoflurane (EI) could reduce temperature thresholds for inducing transient receptor potential vanilloid-1 (TRPV1) channel currents in dorsal root ganglia neurons. (A) TRPV1 channel currents were evoked at 42°C. With the addition of 0.3 mM EI, similar TRPV1 channel currents were evoked at 40°C. All the TRPV1 channel currents were inhibited by capsazepine (CPZ). (B) EI enhanced heat-evoked TRPV1 channel currents in a concentration-dependent manner.