Fig. 5.
The hippocampal levels of parvalbumin and GAD67 determined by the Western blotting 48-h postisoflurane exposure. The isoflurane exposure reduced the levels of parvalbumin (A and B) and GAD67 (A and C) in the isoflurane group. Neuregulin 1 (NRG1)-β1 reversed these reductions in the isoflurane plus NRG1-β1 group (A–C), which was abolished by AG1478 in the isoflurane plus NRG1-β1 plus AG1478 group (A–C). Data are mean ± SD (n = 4 mice for each group; *P < 0.05 vs. the control group; #P < 0.05, ##P < 0.01 vs. the isoflurane group; ++P < 0.01 vs. the isoflurane plus NRG1-β1 group). GAD67 = glutamic acid decarboxylase 67; PV = parvalbumin.