Fig. 4.
Effects of propofol on electrical synapses between fast-spiking cells (FS). (A) A schematic of an electrical and reciprocal chemical synapses between FS with repetitive spike-firing properties of each neuron. (B) A hyperpolarizing current pulse injection to FS1 induced a voltage response in FS2 (arrowhead) and vice versa (double arrowhead). (C) Hyperpolarizing voltage pulses were applied to FS1 and FS2. Current responses in the coupling FS in the control and propofol application were shown in the lower panels. Ten consecutive traces are shown in gray lines, and their average is shown in black. (D) Time courses of the amplitude of electrical coupling conductance before and during propofol application in the FS shown in A–C.