Influence of intraperitoneal leptin treatment (1 μg/g body weight, twice a day) on survival and body temperature after cecal ligation and puncture (CLP)–induced sepsis. (A) Survival after CLP in control mice receiving volume-adapted vehicle (sodium chloride 0.9%, n = 12) or leptin treatment (n = 10) intraperitoneal and monitored for 7 days. Analysis by log-rank test. (B) Body temperature as independent predictor of mortality did not decrease in control mice receiving leptin treatment after CLP compared with that in the vehicle-treated control. Values are expressed as mean ± SEM; *P < 0.05 of two-way ANOVA for repeated measurements followed by a post hoc Bonferroni test for analyses within groups over time.