Evoked-pain default mode network activity is a target and predictor of successful pregabalin (PG) treatment. (A) Left inferior parietal lobule (IPL) region of interest and (B) left posterior cingulate region of interest (both identified from resting connectivity association with baseline clinical pain) display greater evoked-pain deactivation after PG but not after placebo. Percent blood oxygenation level dependent (BOLD) activations are plotted for both pre- and post-PG as well as pre- and postplacebo. Error bars are standard error. (C) Pre-PG IPL evoked-pain BOLD activation is associated with greater clinical pain response to PG. PCC = posterior cingulate cortex; VAS = Visual Analog Scale.