Fig. 3.
Leukocyte count at the end of experiment in all study groups (HCl-SB; n 14; HCl-VILI15; n 7 and HCl-VILI25; n 9; VILI25; n 7). Dotted lines represent baseline values from five healthy mice. Data are expressed as box (median, 25th and 75th percentiles) and whiskers (10th and 90th percentiles). Groups are: HCl-VILI15 and HCl-VILI25, which were instilled in the right bronchus with HCl and subjected to mechanical ventilation, with tidal volume of 15 or 25 ml/kg for 7 h; HCl-SB that was instilled with HCl in right bronchus and left spontaneous breathing for 7 h; VILI25 that was only ventilated with tidal volume of 25 ml/kg for 7 h. *P < 0.05. HCl = hydrochloric acid; VILI = ventilator-induced lung injury; WBC = white blood cell.