Fig. 2.
Kidney lesions assessed by electron microscopy. (A) Individual scores and medians of the different groups of renal alterations by using electron microscopy. (B–D) Typical histological appearance of epithelial cells (proximal tubes) in the renal cortex from Sham, control, and total liquid ventilation (TLV) groups, respectively. In Sham and TLV groups, brush-border microvilli and mitochondria are well preserved. In control group, microvilli are altered (arrowhead) and mitochondria elicited a dramatic loss in density (arrows). (E) Typical histological appearance of the glomerular apparatus in a kidney from control group. This apparatus was well preserved in all groups. (F–H) Typical histological appearances of epithelial cells (connecting tubes) in the renal medulla from Sham, control, and TLV groups, respectively. Major loss in cytosolic density can be seen in the control group but not in Sham and TLV groups. *P < 0.05 versus corresponding control; †P < 0.05 versus Sham and control.