Experiment protocol (schematic) of part II. i, ii, and iii: Ligation of the splenic artery was undertaken 1, 2, and 3 h after administration of ICI 174,864; phase I: establishment of a model of uncontrolled hemorrhagic shock; phase II: administration of ICI 174,864, LR or permissive hypotensive resuscitation; phase III: resuscitation to a mean arterial pressure of 80 mmHg for 2 h; phase IV: survival observation; arrow: bleeding controlled (by ligation of the splenic artery).