Fig. 2.
Tissue water content over time with respect to intervention for brain (A), lung (B), muscle (C), and small bowel (D). Significance levels indicated in the inset to each panel are for the differences between intercepts of the regression over time when compared to either normal saline (NS) (Ref, left of inset) or mannitol (MAN) (Ref, right of inset). For brain, the slope of the regression line is less for NS plus furosemide (FUR) compared to mannitol (P < 0.001). For lung, the slopes for all of the regression lines differ with respect to mannitol (P ≤ 0.003). For muscle, the slopes are similar (P ≥ 0.019). For small bowel, the slope of the regression line for NS differs with respect to mannitol (P = 0.004). As described in the text, the location of the intercept was adjusted so that its value corresponds to the mean of the variable over the course of the experiment, which occurs when the regression line passes through 2.75 h. For brain, the intercepts and slopes are given for each intervention: NS, 79.3 (99.3% CI, 79.1–79.5) and 0.13 (99.3% CI, 0.00–0.26); NS plus furosemide, 79.3 (99.3% CI, 79.0–79.3) and 0.05 (99.3% CI, −0.05 to 0.14); mannitol, 78.0 (99.3% CI, 77.9–78.2) and 0.27 (99.3% CI, 0.14–0.40); HS, 78.8 (99.3% CI, 78.6–78.9) and 0.27 (99.3% CI, 0.17–0.37); and HS plus furosemide, 78.0 (99.3% CI, 77.8–78.2) and 0.16 (99.3% CI, 0.01–0.31). CI and significance levels were adjusted to account for multiple comparisons. See text for additional detail.