Interleukin (IL)-8 (A) and tumor necrosis factor-α (TNF-α) (B) concentrations in the infected lung (a), and the spleen (b) of rabbits with Enterobacter aerogenes unilateral pneumonia according to the mechanical ventilation strategy (i.e., “adverse” or “protective”), and the position (i.e., supine position [SP] or prone position [PP]). Results are expressed as median ± IQR. It is worth noting that IL-8 release was decreased within the pulmonary and the systemic compartment in the animals turned into PP. In contrast, no significant difference was seen regarding TNF- α. *P < 0.05 between SP and PP groups. IQR = interquartile range.