Fig. 2. Differential modification of specific and nonspecific thalamocortical functional connectivity across the states of consciousness. The upper three panels (A, B , and C ) and the lower three panels (D, E , and F ) illustrate respectively the significant specific and nonspecific thalamic connections derived from one-sample t tests in the states of wakeful baseline, deep sedation, and recovery. Note the different distributions of specific and nonspecific thalamocortical connectivity at baseline and the greater reduction in nonspecific versus specific connectivity in deep sedation.