Fig. 10. Lung bacterial burden of Pseudomonas aeruginosa after 24 h of ceftazidime nebulization. Lung segments (triangles) were sampled 3 h after the eighth aerosol in the aerosol group, 24 h after the start of continuous infusion in the intravenous group (IV), and 48 h after the bacterial inoculation in the untreated control group. Lung bacterial burden was significantly lower in the aerosol group compared with the intravenous and control groups. The difference was not statistically significant between intravenous and control groups. The grey area indicates the lower limit of quantitation for bacterial counts. Lung segments in this area are characterized by bacterial counts ranging between 0 colony-forming unit (CFU/g) (sterile) and 102CFU/g. (Reprinted from Ref. 76with the permission of the publisher.) NS = not significant.