Fig. 1. Effect of IP DNP on the withdrawal threshold to pressure applied to the hindpaw in rats with spinal nerve ligation (A ) and normal rats (B ). Withdrawal thresholds are expressed as the mean ± SD for six rats in each group. *P < 0.05 compared with SAL-treated group at each time point (Student–Neuman–Keuls post hoc  test after two-way repeated-measures ANOVA). DNP = donepezil; IP = intraperitoneal; SAL = saline.