Fig. 4. Xe as an adjunct to subtherapeutic hypothermia (outcome). Rats were subjected to 70-min awake normothermic (37.5°C) middle cerebral artery occlusion and 90-min reperfusion. They were then randomly allocated to control of pericranial temperature at 37.5° or 36.0°C with or without exposure to 30% Xe for 20 h. Neurologic score and cerebral infarct size were measured 4 weeks postischemia. Open circles  indicate individual animal values. Horizontal lines  indicate mean values for (A ) neurologic score and (B ) total, (C ) cortical, and (D ) subcortical infarct sizes. For neurologic scores, 0 = no neurologic deficit (potential range 0–48). P  values indicate main effect. *P < 0.05 versus  37.5°C/0% Xe. Xe = Xenon.