Fig. 2. The projected position of the voxel within the parietal cortex for the proton magnetic resonance spectroscopy (¹HMRS) scan is illustrated on a surface reconstructed three-dimensional mask from one of the children (A ) and on the corresponding three orthogonal views (B ). The figure also shows the derived ¹HMRS spectrum from the parietal cortex of a child anesthetized with sevoflurane analyzed by LCModel (C ). The spectrum shown in C  is of high quality with sufficient water suppression and excellent spectral resolution to resolve at least 6–10 metabolites. The raw unsmoothed spectrum is shown (black ) in addition to the LCModel fitted spectral output (red solid line ). Glu = glutamate; Glx = glutamate and glutamine; mI = myo-inositol; MM = macromolecules; NAA = N -acetylaspartate; tCho = total choline; tCr = total creatine.