Fig. 5. Xenon reversibly decreased the amplitudes of α-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid (AMPA) receptor-mediated electrically evoked excitatory postsynaptic currents (EPSCs) but not N -methyl-D-aspartate (NMDA) receptor-mediated electrically evoked EPSCs in the spinal lamina IX neurons. Averaged traces of six consecutive AMPA receptor-mediated evoked EPSCs at −70 mV before, during, and after xenon (A ). Time course of the relative peak amplitudes of AMPA receptor-mediated evoked EPSCs before, during, and after xenon (B ). Summaries of the suppressive effects of xenon and 6-cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX) on AMPA receptor-mediated evoked EPSCs relative to control value (C ). Averaged traces of six consecutive NMDA receptor-mediated evoked EPSCs at +40 mV before and during xenon (D ). Time course of the relative peak amplitudes of NMDA receptor-mediated evoked EPSCs before and during xenon (E ). Summaries of the suppressive effects of xenon and D,L-2-amino-5-phosphonopentanoic acid (AP-5) on NMDA receptor-mediated evoked EPSCs relative to control value (F ). *P < 0.01. The time scales of electrically evoked EPSCs are 1,000 times as small as those of exogenous agonist-induced currents. HP = holding potential; ns = not significant.