Fig. 2. Xenon inhibited exogenous α-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid (AMPA)-induced currents. Representative traces showing AMPA (10 μM)-induced currents in the spinal lamina IX neurons at −70 mV, which were reversibly reduced by 50% xenon (A ). Fifty percent xenon decreased the peak amplitudes of AMPA-induced currents to 72 ± 9% of control values and the integrated area to 73 ± 13% of control values, respectively (B, C ). Representative traces showing AMPA-induced currents in the spinal lamina IX neurons at −70 mV, which were reversibly reduced by 75% xenon (D ). Seventy-five percent xenon decreased the peak amplitudes of AMPA-induced currents to 67 ± 12% of control values and the integrated area to 62 ± 12% of control values (E, F ). *P < 0.01. HP = holding potential.