Fig. 1. Causes of liver insults, definitions, and key points of intensive care unit (ICU) acquired acute liver injury, hepatic dysfunction, and acute liver failure. ALP = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; γ-GT = γ-glutamyl transpeptidase; ICG-PDR = indocyanine green plasma disappearance rate; INR = international normalized ratio.