Fig. 2. Volatile anesthetics' effect on glycine responses in homomeric α1 wild-type (WT), α1 (M287L), and α1 (Q266I) expressed in Xenopus  oocytes. Isoflurane (0.3 mM) and chloroform (1 mM) potentiation of glycine responses (with a concentration that induced a current that is 5% of the maximal current, effective concentration 5, or EC⁵) in (A ) α1 wild-type (n = 6) and α1 (M287L) (n = 5), and (B ) α1 wild-type (n = 4) and α1 (Q266I) (n = 4). Values are means ± SEM; *P < 0.01 versus  corresponding wild-type, Student t  test analysis.