Fig. 3. Effects of hind paw incision on peripheral (A ) C5a and (B ) interleukin-1β levels. The levels of these mediators were measured in hind paw plantar skin at baseline and at the 2–72 h time-points after incision. The selected time-points were based on the behavior data presented in fig. 2. Different groups of mice were used for each time point (n = 6 per group). Data are presented as mean ± SEM and were analyzed by two-way ANOVA with post hoc Bonferroni correction. **P < 0.01, ***P < 0.001, and ###P < 0.001 difference from control antibody group. Ab = antibody; AGr1 = anti-Gr-1; IL = interleukin.