Fig. 4. The fraction of patients requiring excess hospital length of stay (LOS), relative to the national average LOS for a type of case, as a function of cumulative (not necessarily contiguous) minutes in a triple low state (mean arterial pressure [MAP] less than 75 mmHg, Bispectral Index less than 45, and minimum alveolar concentration [MAC] fraction less than 0.8). The fraction of patients requiring excess LOS increased significantly as the duration of triple low minutes increased and was significantly greater than baseline (no triple low minutes) at all times exceeding 30 min.