Fig. 3. Thirty-day all-cause mortality as a function of cumulative (not necessarily contiguous) minutes in a triple low state (mean arterial pressure [MAP]rsqb] less than 75 mmHg, Bispectral Index less than 45, and minimum alveolar concentration [MAC] fraction less than 0.8). Mortality was significantly increased from baseline (no triple low minutes) when cumulative triple low duration was 31–45 min and when it exceeded 60 min.