Fig. 6. Hepatic injury after acute kidney injury (AKI). Hepatic injury with increased hepatic necrosis and vacuolization after renal ischemia reperfusion. Representative photomicrograph of liver (×400, hematoxylin and eosin staining) of mice subjected to sham surgery (A ) or to 30 min of renal ischemia and 24 h of reperfusion (B ). Ischemic AKI rapidly caused nuclear and cytoplasmic degenerative changes, periportal venous hepatocyte necrosis (arrows ), and marked hepatic vacuolization and congestion.