Fig. 4. Photomicrographs showing OX-42 immunoreactivity in the ipsilateral cuneate nucleus (CN) on day 7 after chronic constriction injury (CCI) in rats that received whole-body hypothermic treatment. There was little OX-42 immunoreactivity present in the CN of sham-operated rats treated with whole-body normothermia (A ), mild whole-body hypothermia (B ), or deep whole-body hypothermia (C ). In preinjury, 5 h, 1 day, and 3 days postinjury groups, OX-42 immunoreactivity was decreased in the CN of CCI rats that received mild (E, H, K, N ) or deep whole-body hypothermia (F, I, L, O ) compared with those that received whole-body normothermia (D, G, J, M ). In the 5 days postinjury group, OX-42 immunoreactivity was decreased in the CN of CCI rats receiving deep whole-body hypothermia (R ), but not in those receiving whole-body normothermia (P ) or mild whole-body hypothermia (Q ). Bar = 100 μm.