Fig. 3. Photomicrographs showing OX-42 immunoreactivity in the ipsilateral cuneate nucleus (CN) 7 days after chronic constriction injury (CCI) in rats that received regional hypothermic treatment. Little OX-42 immunoreactivity was observed in the CN of sham-operated rats treated with regional normothermia (A ), mild regional hypothermia (B ), or deep regional hypothermia (C ). In the preinjury and 5 h postinjury groups, OX-42 immunoreactivity decreased in the CN of CCI rats that received mild regional hypothermia (E, H ) or deep regional hypothermia (F, I ), but not in those that received regional normothermia (D, G ). In 1 day, 3 days, and 5 days postinjury groups, there was intense OX-42 immunoreactivity in the CN of CCI rats treated with regional normothermia (J, M, P ), mild regional hypothermia (K, N, Q ), and deep regional hypothermia (L, O, R ). Bar = 100 μm.