Fig. 5. Complete Freund's adjuvant (CFA)-induced thermal hyperalgesia in protein kinase C knockout mice. (A ) PKCα knockout mice developed CFA-induced thermal hyperalgesia, which is not significantly different from wild-type littermate control mice. (B–D ) Protein kinase Cβ, γ, and δ knockout mice develop attenuated CFA-induced thermal hyperalgesia compared with wild-type littermate control mice. Representing group main effects, *P < 0.05, **P < 0.01; group x time effects were not statistically significant. For all experiments, the experimenter was blind to genotype of the animals. KO = knockout; WT = wild type.