Fig. 3. Intraocular pressure (IOP) over time during surgery for the supplemental fluid (A ) and eye drop (B ) interventions. Half error bars are means ± SDs. Albumin did not reduce time-weighted average (TWA) IOP [P = 0.34 for TWA IOP and P = 0.09 for mean IOP collapsing over time (A )]. However, brimonidine reduced both TWA IOP (P = 0.023) and the mean IOP collapsing over time (B , P = 0.003). Rate of IOP increase was slower for patients receiving albumin than those receiving crystalloid (P = 0.031), but no different between brimonidine and placebo (P = 0.81). Both interventions reduced IOP by end of surgery. IntraOP = all intraoperative data. OBS = observation. PreOP = preoperative data.