Fig. 5. Effect of indinavir on oral methadone disposition. Shown are plasma R-methadone (A ), R-EDDP (2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine) (B ), S-methadone (C ), and S-EDDP (D ) concentrations. Subjects received 11.0 mg oral methadone HCl (9.9 mg free base). Each data point is the mean ± SD (n = 12). Some SD are omitted for clarity.

Fig. 5. Effect of indinavir on oral methadone disposition. Shown are plasma R-methadone (A ), R-EDDP (2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine) (B ), S-methadone (C ), and S-EDDP (D ) concentrations. Subjects received 11.0 mg oral methadone HCl (9.9 mg free base). Each data point is the mean ± SD (n = 12). Some SD are omitted for clarity.

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