Fig. 1. Indinavir effects on first-pass and hepatic cytochrome P4503A (CYP3A) activity assessed using alfentanil as a CYP3A probe. Pupil diameter change from baseline (miosis) was used as a surrogate for alfentanil plasma concentrations. Shown is miosis after 43 μg/kg oral alfentanil (A ) and 15 μg/kg intravenous alfentanil (B ). Each data point is the mean ± SD (n = 12).

Fig. 1. Indinavir effects on first-pass and hepatic cytochrome P4503A (CYP3A) activity assessed using alfentanil as a CYP3A probe. Pupil diameter change from baseline (miosis) was used as a surrogate for alfentanil plasma concentrations. Shown is miosis after 43 μg/kg oral alfentanil (A ) and 15 μg/kg intravenous alfentanil (B ). Each data point is the mean ± SD (n = 12).

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