Fig. 6. Xenon does not affect L-type calcium channel currents. Depolarizing voltage steps from −70 to 0 mV evoked barium currents through calcium channels. P/Q-, N-, and T-type calcium channels were blocked pharmacologically. After stable control recordings, xenon was applied and did not change (95.4 ± 7.4% of control; 95% CI 77.7–113.1; n = 6; P = 0.650) the charge transfer (time integral of the current trace) through the channels. Application of the specific L-type calcium channel antagonist nifedipine (5 μM; nif) in some experiments markedly reduced the charge transfer (47.0 ± 13.1%), indicating that the recorded currents were at least to ∼50% mediated by calcium channels of the L-type.