Fig. 2.  Identification of single nucleotide polymorphisms (SNPs) located in the 5′-untranslated fragment and beginning of the coding sequence of the CHRM3 gene on chromosome 1. Plot of combined −log of P  values for allelic frequency difference (vertical axis) versus  position on chromosome 1 (in kb, horizontal axis) for SNPs analyzed by the Illumina Human 610-Quad microarray within the locus of CHRM3 gene (A ). SNPs in linkage disequilibrium (according to HapMap Release 27) with rs2355230 (measured as R  ²on left vertical axis) in relation to the position on chromosome 1 (expressed in kb on horizontal axis), and approximate position of the coding sequence of the CHRM3 gene. The right side vertical axis indicates the recombination rate (in cM/Mb) along the nucleotide sequence on chromosome 1 fragment surrounding rs2355230 (B ).