Fig. 6. Trif deficiency has no effect on peritoneal lavage and serum cytokine levels during polymicrobial sepsis. WT and Trif−/−mice underwent sham or CLP procedures. Twenty-four hours later, peritoneal lavage and blood were collected. Peritoneal lavage and serum IL-6, IL-10, TNFα, KC, MCP-1, and MIP-2 were measured with a multiplex fluorescent bead-based immunoassay. (A ) Peritoneal lavage cytokines. (B ) Serum cytokines. Each error bar represents mean ± SE. The number of animals in each group: WT-Sham = 3, WT-CLP = 4, Trif−/−-Sham = 3, Trif−/−-CLP = 6. CLP = cecum ligation and puncture; IL = interleukin; KC = keratinocyte chemoattractant; MCP-1 = monocyte chemoattractant protein-1; MIP-2 = macrophage inflammatory protein-2; MyD88 = myeloid differentiation factor 88; TNF = tumor necrosis factor; Trif = TIR-domain-containing adaptor protein inducing interferon-β mediated transcription-factor; WT = wild-type.

Fig. 6. Trif deficiency has no effect on peritoneal lavage and serum cytokine levels during polymicrobial sepsis. WT and Trif−/−mice underwent sham or CLP procedures. Twenty-four hours later, peritoneal lavage and blood were collected. Peritoneal lavage and serum IL-6, IL-10, TNFα, KC, MCP-1, and MIP-2 were measured with a multiplex fluorescent bead-based immunoassay. (A ) Peritoneal lavage cytokines. (B ) Serum cytokines. Each error bar represents mean ± SE. The number of animals in each group: WT-Sham = 3, WT-CLP = 4, Trif−/−-Sham = 3, Trif−/−-CLP = 6. CLP = cecum ligation and puncture; IL = interleukin; KC = keratinocyte chemoattractant; MCP-1 = monocyte chemoattractant protein-1; MIP-2 = macrophage inflammatory protein-2; MyD88 = myeloid differentiation factor 88; TNF = tumor necrosis factor; Trif = TIR-domain-containing adaptor protein inducing interferon-β mediated transcription-factor; WT = wild-type.

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