Fig. 1.  Changes in mean arterial blood pressure (A ), cardiac index (B ), heart rate (C ), and body temperature (D ) in response to lipopolysaccharide infusion and treatment with the selective toll-like receptor 4 antagonist, TAK-242 (6 mg/24 h, n = 7), vehicle (n = 7), or norepinephrine (NE, n = 6), titrated to maintain mean arterial pressure (MAP) at baseline levels. Data are expressed as mean ± SEM. Differences between treatments were evaluated by ANOVA using time points 0, 12, and 24 h after commencement of lipopolysaccharide infusion and were considered significant at P ≤ 0.05. *, a significant difference between TAK-242 and vehicle; and †, a significant difference between vehicle and NE.