Fig. 5. Propofol-hyposensitive receptors retain normal sensitivity to other positive allosteric modulators. (A ) Glycine-evoked currents were enhanced by ethanol (ETOH, 100 mM) and isoflurane (ISO, 500 μM) in the F380A mutant. (B ) Potentiation of the glycine-evoked current in wild type and F380A GlyRs by positive allosteric modulators. (C ) γ-aminobutyric acid-evoked currents were enhanced by etomidate (ETO, 5 μM) and isoflurane (ISO, 500 μM) in the F385A mutant. (D ) Potentiation of the γ-aminobutyric acid type A receptor (GABAAR) wild type (WT) and F385A mutant by propofol, etomidate, isoflurane, alphaxalone, and trichloroethanol (TCEt). WT values are shown in gray, whereas the mutant responses are shown in white. The bars represent the mean ± SEM. *** Significance of P < 0.001.