Fig. 2. Isoflurane causes impairment in short- and long-term memory that is prevented by preadministration of L-655,708. Differences are represented using asterisks. When testing for effects of L-655,708, comparisons were made against the corresponding vehicle-treated groups; differences are represented using daggers. (A ) Freezing behavior to the context studied 30 min after training. (B ) Freezing behavior to the audible cue 90 min after training. (C ) Freezing behavior to the context 2 days after training. (D ) Freezing behavior to the audible cue 2 days after training. (1-h oxygen [O2], vehicle: n = 12; 1-h O2, L-655,708: n = 11; 1-h isoflurane (Iso), vehicle: n = 11; 1-h isoflurane, L-655,708: n = 9; 24-h isoflurane, vehicle: n = 12; 24-h isoflurane, L-655,708: n = 12.) *P < 0.05 and **P < 0.01, ***P < 0.001 compared with O2-treated subjects, 1 h, vehicle; †P < 0.05 and ††P < 0.01 compared with vehicle control.