Fig. 5. Cross-modal interactions between visual and auditory networks correlate with the level of consciousness during propofol sedation. (A ) Connectivity between primary visual cortex (used as seed region of interest) and primary auditory cortex (shown in black) shows a linear correlation with the level of consciousness. Results are thresholded for display at uncorrected P less than 0.001 and are shown on the mean structural T1 magnetic resonance scan of the subjects. y indicates the Montreal National Institute coordinates of section plane. (B ) Effect sizes (expressed as group mean and 90% CI) for connectivity between auditory and visual cortices during wakefulness (W), mild sedation (MS), unconsciousness (U), and recovery of consciousness (R).