Fig. 4.  Micrographs of lumbar spinal cords 14 days after spinal cord ischemia show morphologic characteristics of transplanted MSCs or HGF gene-modified MSCs. (A ) With immunoperoxidase staining with diaminobenzidine and counterstaining with hematoxylin, bromodeoxyuridine (BrdU) reactivity is present in the nuclei of donor cells (brown, original magnification, 200×). (B ) Number of BrdU-positive cells in the ventral gray matter. No BrdU-positive cells can be detected in the spinal cords of sham and control animals. There was no significant difference in the BrdU-positive cells count among the groups of MSCs A, HGF-MSCs A, MSCs B, and HGF-MSCs B (chi-square = 1.335, P = 0.721). A = ischemia for 40 min; B = ischemia for 50 min; HGF = hepatocyte growth factor; HGF-MSCs = HGF gene-modified marrow stromal cells; MSCs = marrow stromal cells.

Fig. 4.  Micrographs of lumbar spinal cords 14 days after spinal cord ischemia show morphologic characteristics of transplanted MSCs or HGF gene-modified MSCs. (A ) With immunoperoxidase staining with diaminobenzidine and counterstaining with hematoxylin, bromodeoxyuridine (BrdU) reactivity is present in the nuclei of donor cells (brown, original magnification, 200×). (B ) Number of BrdU-positive cells in the ventral gray matter. No BrdU-positive cells can be detected in the spinal cords of sham and control animals. There was no significant difference in the BrdU-positive cells count among the groups of MSCs A, HGF-MSCs A, MSCs B, and HGF-MSCs B (chi-square = 1.335, P = 0.721). A = ischemia for 40 min; B = ischemia for 50 min; HGF = hepatocyte growth factor; HGF-MSCs = HGF gene-modified marrow stromal cells; MSCs = marrow stromal cells.

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