Fig. 5. Representative immunofluorescence staining of skin tissue 3 days after injection of 1 nmol mismatched (MM) NR1-1 small interfering RNA (siRNA). (A ) and skin tissue 3 days after injection of 1 nmol NR1-1 siRNA (B ). The arrows show NR1 immunofluorescence at dermal-epidermal junction (bar = 50 μm). Epider = epidermis; Der = dermis. (C ) Significant decrease level of NR1 fluorescence intensity was shown in the NR1-1 siRNA-treated skin compared with MM-NR1-1 siRNA-treated skin. *P < 0.05 compared with injection of mismatched NR1-1 siRNA. MM-siRNA: mismatched NR1-1 siRNA, siRNA: NR1-1 siRNA. Values are median (upper and lower quartiles).