American Society of Anesthesiologists

$Fig. 6. Computer simulation of the percentage of the amount of infused Ringer's solution that still remains in the plasma, calculated as (v c−V c) · 100/infused volume, based on typical kinetic data for a brisk 30-min infusion in volunteers (A ) and a much slower infusion during 60 min in perioperative patients (B ). The light lines show what the fraction would have been if distribution from the plasma to the interstitial fluid space was immediate. Cl = clearance; Cl d= distribution clearance; R o= rate of infusion; V cand V t= size of central and peripheral fluid spaces, respectively, which are termed v cand v twhen expanded.$

Fig. 6. Computer simulation of the percentage of the amount of infused Ringer's solution that still remains in the plasma, calculated as (v ^c−V ^c) · 100/infused volume, based on typical kinetic data for a brisk 30-min infusion in volunteers (A ) and a much slower infusion during 60 min in perioperative patients (B ). The light lines show what the fraction would have been if distribution from the plasma to the interstitial fluid space was immediate. Cl = clearance; Cl ^d= distribution clearance; R ^o= rate of infusion; V ^cand V ^t= size of central and peripheral fluid spaces, respectively, which are termed v ^cand v ^twhen expanded.

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