Fig. 4.  Endogenous albumin augments plasma volume expansion after hemorrhage despite adequate fluid replacement. Computer simulation based on kinetic data from Ref.44in which volunteers received infusions of 25 ml/kg acetated Ringer's solution on three separate occasions. Before two of these infusions, 450 and 900 ml blood was withdrawn. Positive values indicate translocation of albumin from the interstitial fluid to the plasma, whereas negative values show that albumin leaves the plasma. Hgb = hemoglobin.