Fig. 7. (A –C ) Sciatic nerve, surrounding muscle, and connecting tissue stained with hematoxylin and eosin 1 week after administration of slow-release lidocaine sheet (SRLS) or (D –F ) lidocaine. (B , C ) High-magnification images of (A ); (B ) focuses on the muscle, and (C ) focuses on the nerve. Signs of inflammation were slightly detected in the muscle (B ), but little to no inflammation was detected in the nerve (C ). (E , F ) High-magnification images of (D ); (E ) focuses on the muscle, and (F ) focuses on the nerve. The macrophages, lymphocytes, and plasma cells were moderately observed in the muscle and nerve. Atrophy of the muscle fibers can also be observed in (E ). M = muscle; N = sciatic nerve. Scale bars = 500 μm.