Fig. 3. Caveolin expression and reduction in infarct size. Mice underwent 30-min coronary artery occlusion followed by 2-h reperfusion after 24-h recovery from pretreatment with oxygen (control) or isoflurane (anesthetic preconditioning [APC]) in wild-type (WT), caveolin-1 knockout (Cav-1 KO), and caveolin-3 knockout (Cav-3 KO) mice. (A ) Area at risk (AAR) as a percent of left ventricle (LV) was not different between groups. (B ) Infarct size was reduced by APC in WT and Cav-1 KO mice but not Cav-3 KO mice. *P < 0.05 treated group versus  control. Ctrl = control.