Fig. 5. Regional net 18F-fluorodeoxyglucose uptake rate (Ki) and specific Ki(Kis) in supine sheep after 2 h of mechanical ventilation with positive end-expiratory pressure = 0 cm H2O and plateau pressure of 30-32 cm H2O, without (control, n = 6, A , B ) and with mild endotoxemia (endotoxin, n = 6, C , D ). Control values of Kiand Kis(A , B ) are quite homogeneous within and between animals. Mild endotoxemia produced an increase in the average whole-lung values of Kiand Kiswith significant regional heterogeneity (C , D ), larger in dorsal regions. *P < 0.05 between middle and ventral regions; †P < 0.05 dorsal versus ventral regions; ‡P < 0.05 dorsal versus middle regions; #P < 0.05 endotoxin versus control group. Circles represent individual data points.