Fig. 3. Pain sensitization after two consecutive surgeries performed during sevoflurane (incision group, empty squares , n = 5) or remifentanil anesthesia at 2.66 μg · kg−1· min−1( filled squares , n = 9) or 0.66 μg · kg−1· min−1( filled triangles , n = 7). Each point represents the mean change in nociceptive thresholds compared with baseline, standardized to the control group (represented by the broken line , n = 9). Vertical bars show SD. Negative values indicate pronociceptive effects. Remifentanil was administered at a dose of 2.66 μg · kg−1· min−1(80 μg/kg; A and B ) or 0.66 μg · kg−1· min−1(20 μg/kg; C ) over 30 min. A , plantar latency (seconds); B and C , mechanical thresholds (grams). * P < 0.05 compared with control group.
