Fig. 3. Systolic blood pressure (mmHg) was measured in awake db/db mice after infusion of whole blood (n = 10), after infusion of PolyHeme (Northfield Laboratories, Evanston, IL) (1.08 g hemoglobin/kg body weight, n = 8), or after infusion of PolyHeme in mice that were pretreated with inhaled nitric oxide (iNO) (80 ppm for 1 h; PolyHeme + iNO, n = 8). *P < 0.05 differs versus  whole blood group and PolyHeme + iNO group.