American Society of Anesthesiologists

$Fig. 2. Xenon does not require the SUR1 subunit to activate KATPchannels. (A ) Xenon activation of whole cell Kir6.2ΔC26 currents. Plotted is the mean holding current at −20 mV every 15 s. Note the enhanced rundown compared with channels containing the SUR1 subunit.15,19Dashedline is approximation of slower phase of rundown. (B ) Mean data from recordings performed on Kir6.2ΔC26, Kir1.1, and K185Q/SUR1 currents summarizing the effects of activators and inhibitors of these channels. Expressed is the holding current at −20 mV in the presence of the drug as a fraction of the current in the absence of the drug. Note the lack of effect of tolbutamide (Tb) and diazoxide (Dz) on Kir6.2ΔC26 currents. (C ) Whole cell Kir6.2-K185Q/SUR1 current is sensitive to tolbutamide but not xenon. Numbers (N) are given above the bars. *P < 0.05 compared with control. **P < 0.01 compared with control.$

Fig. 2. Xenon does not require the SUR1 subunit to activate K^ATPchannels. (A ) Xenon activation of whole cell Kir6.2ΔC26 currents. Plotted is the mean holding current at −20 mV every 15 s. Note the enhanced rundown compared with channels containing the SUR1 subunit.15,19 Dashedline is approximation of slower phase of rundown. (B ) Mean data from recordings performed on Kir6.2ΔC26, Kir1.1, and K185Q/SUR1 currents summarizing the effects of activators and inhibitors of these channels. Expressed is the holding current at −20 mV in the presence of the drug as a fraction of the current in the absence of the drug. Note the lack of effect of tolbutamide (Tb) and diazoxide (Dz) on Kir6.2ΔC26 currents. (C ) Whole cell Kir6.2-K185Q/SUR1 current is sensitive to tolbutamide but not xenon. Numbers (N) are given above the bars. *P < 0.05 compared with control. **P < 0.01 compared with control.

This Feature Is Available To Subscribers Only