Fig. 2. Time course of the effect of intraplantar injection of complete Freund's adjuvant (CFA) on blood oxygenation level-dependent (BOLD) signal intensity in the cingulate cortex (CG), somatosensory cortex (S1), insula cortex (IC), medial halamic region (mTH), and lateral thalamic region (lTH) in wild-type (WT) and prodynorphin (PDYN) knockout (KO) mice. Representative activation maps (overlaid on anatomy) correspond to composite images at 0 or 6 h (A-i : CG, B-i : S1, C-i : IC, D-i ; mTH, E-i ; lTH) after intraplantar injection of CFA in WT and KO mice. Intraplantar injection of CFA produced a significant increase in BOLD signal in the CG (A-ii ), S1 (B-ii ), IC (C-ii ), mTH (D-ii ), and lTH (E-ii ) of wild-type mice. Data are expressed as percentages of the corresponding baseline levels with mean ± SEM for five mice.